|
|
 |
Intro
Welcome to the laboratory of Scott C. Fahrenkrug at the University of Minnesota. The lab is focused on classical and quantitative genetics, functional genomics, and genetic engineering to develop pigs for medical applications, including the treatment and study of diabetes and cystic fibrosis. Projects underway in the lab include:
- Transposon-based manipulation of the pig genome to develop medical products, large-animal models of human genetic disease, and animals with enhanced agricultural production traits.
- Diabetes - we are studying the genetic engineering of pigs to increase the safety and efficacy of islet xenotransplantation to treat type 1 diabetes.
- Cystic Fibrosis - we are genetically engineering pigs to create an RNA interference-based large animal model of cystic fibrosis.
- Functional Genomics and Proteomics based profiling of gene-expression in pig and cattle tissues to identify candidate genes for superior medical and agricultural performance.
- Porcine Islet Biology - we are examining the protein and transcript profile in islet tissue to identify markers of quality, efficacy, immugenicity, and yield.
- Dairy Cattle Performance -we are examining the transcript profile in dairy cattle that display variation in performance and health traits
- Development of the Minnesota Animal Genome Ontology database (MANGOdb), a species independent Comparative and Functional Genomics database for the storage and analysis of phenotypic, genetic, and gene-expression data.
|
| |
Public Plasmid Info
Plasmid vector maps and sequences are now available for download.
Downloads
|
|
Pig Oligo Array
The website for the second generation swine protein-annotated oligonucleotide array is now availble with annotations and other information available for download.
Pigoligoarray.org
|
|
